1. Therefore, greater GPCR selectivity may be obtained by targeting allosteric sites . 2. RNR1 contains both allosteric sites , mediating regulation of substrate specificity and activity. 3. However, not all inhibitors that bind at allosteric sites are mixed inhibitors. 4. Allosteric sites may represent a novel drug target.5. This may be accomplished by binding to the active site or the allosteric site . 6. In addition, sGC contains an allosteric site , to which sGC stimulators bind. 7. The second form of " non-competitive antagonists " act at an allosteric site . 8. The site to which the effector binds is termed the " allosteric site ". 9. Under resting conditions, it is thought that chloride is bound to allosteric sites in prestin. 10. These allosteric sites are involved in creating the ligand-enzyme specificity seen in most bioactive enzymes.
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